Some new biologically active metal-based sulfonamide
Identifieur interne : 000629 ( Main/Exploration ); précédent : 000628; suivant : 000630Some new biologically active metal-based sulfonamide
Auteurs : Zahid H. Chohan [Pakistan] ; Hazoor A. Shad [Pakistan] ; Moulay H. Youssoufi [Maroc] ; TAIBI BEN HADDA [Maroc]Source :
- European journal of medicinal chemistry [ 0223-5234 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Sulfonamide, Métal divalent Complexe, Antibactérien, Antifongique, Cytotoxicité, Activité biologique, In vitro, Synthèse chimique, Cuivre Complexe, Cobalt Complexe, Nickel Complexe, Zinc Complexe, Base Schiff, Brome Composé organique, Complexe aqua, Coordinat organique, Conductivité ionique, Susceptibilité magnétique, Imine, Propriété électrique, Propriété magnétique, Benzènesulfonamide(N-[pyrimidin-2-yl]-4-[5-bromo-2-hydroxybenzylidèneamino]).
English descriptors
- KwdEn :
- Antibacterial agent, Antifungal agent, Aqua complex, Biological activity, Bromine Organic compounds, Chemical synthesis, Cobalt Complexes, Copper Complexes, Cytotoxicity, Divalent metal Complexes, Electrical properties, Imine, In vitro, Ionic conductivity, Magnetic properties, Magnetic susceptibility, Nickel Complexes, Organic ligand, Schiff base, Sulfonamide, Zinc Complexes.
Abstract
A new series of sulfonamide derived Schiff bases has been synthesized by a condensation reaction of various sulfonamides with aromatic aldehydes. The so obtained sulfonamide were further investigated for their chelation and biological properties with first row d-transition metal ions [cobalt(II), copper(II), nickel(II) and zinc(II)]. The nature of bonding and structure of all the synthesized compounds have been inferred from magnetic susceptibility and conductivity measurements, IR, 1H and 13C NMR, electronic spectral, mass spectrometry and CHN analysis data. The structure of ligand, 4-{[(E)-(5-bromo-2-hydroxy phenyl)methyldene]amino}-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide has also been determined by X-ray diffraction method. An octahedral geometry has been suggested for all the complexes. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal and cytotoxic properties. The result of these studies have revealed that all compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against various fungal strains.
Affiliations:
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Chohan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, Bahauddin Zakariya University</s1><s2>Multan-60800</s2><s3>PAK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Pakistan</country><wicri:noRegion>Multan-60800</wicri:noRegion></affiliation></author><author><name sortKey="Shad, Hazoor A" sort="Shad, Hazoor A" uniqKey="Shad H" first="Hazoor A." last="Shad">Hazoor A. Shad</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, Bahauddin Zakariya University</s1><s2>Multan-60800</s2><s3>PAK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Pakistan</country><wicri:noRegion>Multan-60800</wicri:noRegion></affiliation></author><author><name sortKey="Youssoufi, Moulay H" sort="Youssoufi, Moulay H" uniqKey="Youssoufi M" first="Moulay H." last="Youssoufi">Moulay H. Youssoufi</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratoire Chimie des Matériaux, Faculté des Sciences, Université Mohammed Premier</s1><s2>60000 Oujda</s2><s3>MAR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Maroc</country><wicri:noRegion>60000 Oujda</wicri:noRegion></affiliation></author><author><name sortKey="Taibi Ben Hadda" sort="Taibi Ben Hadda" uniqKey="Taibi Ben Hadda" last="Taibi Ben Hadda">TAIBI BEN HADDA</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratoire Chimie des Matériaux, Faculté des Sciences, Université Mohammed Premier</s1><s2>60000 Oujda</s2><s3>MAR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Maroc</country><wicri:noRegion>60000 Oujda</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">European journal of medicinal chemistry</title><title level="j" type="abbreviated">Eur. j. med. chem.</title><idno type="ISSN">0223-5234</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">European journal of medicinal chemistry</title><title level="j" type="abbreviated">Eur. j. med. chem.</title><idno type="ISSN">0223-5234</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibacterial agent</term><term>Antifungal agent</term><term>Aqua complex</term><term>Biological activity</term><term>Bromine Organic compounds</term><term>Chemical synthesis</term><term>Cobalt Complexes</term><term>Copper Complexes</term><term>Cytotoxicity</term><term>Divalent metal Complexes</term><term>Electrical properties</term><term>Imine</term><term>In vitro</term><term>Ionic conductivity</term><term>Magnetic properties</term><term>Magnetic susceptibility</term><term>Nickel Complexes</term><term>Organic ligand</term><term>Schiff base</term><term>Sulfonamide</term><term>Zinc Complexes</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Sulfonamide</term><term>Métal divalent Complexe</term><term>Antibactérien</term><term>Antifongique</term><term>Cytotoxicité</term><term>Activité biologique</term><term>In vitro</term><term>Synthèse chimique</term><term>Cuivre Complexe</term><term>Cobalt Complexe</term><term>Nickel Complexe</term><term>Zinc Complexe</term><term>Base Schiff</term><term>Brome Composé organique</term><term>Complexe aqua</term><term>Coordinat organique</term><term>Conductivité ionique</term><term>Susceptibilité magnétique</term><term>Imine</term><term>Propriété électrique</term><term>Propriété magnétique</term><term>Benzènesulfonamide(N-[pyrimidin-2-yl]-4-[5-bromo-2-hydroxybenzylidèneamino])</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new series of sulfonamide derived Schiff bases has been synthesized by a condensation reaction of various sulfonamides with aromatic aldehydes. The so obtained sulfonamide were further investigated for their chelation and biological properties with first row d-transition metal ions [cobalt(II), copper(II), nickel(II) and zinc(II)]. The nature of bonding and structure of all the synthesized compounds have been inferred from magnetic susceptibility and conductivity measurements, IR, <sup>1</sup>H and <sup>13</sup>C NMR, electronic spectral, mass spectrometry and CHN analysis data. The structure of ligand, 4-{[(E)-(5-bromo-2-hydroxy phenyl)methyldene]amino}-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide has also been determined by X-ray diffraction method. An octahedral geometry has been suggested for all the complexes. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal and cytotoxic properties. The result of these studies have revealed that all compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against various fungal strains.</div></front></TEI><affiliations><list><country><li>Maroc</li><li>Pakistan</li></country></list><tree><country name="Pakistan"><noRegion><name sortKey="Chohan, Zahid H" sort="Chohan, Zahid H" uniqKey="Chohan Z" first="Zahid H." last="Chohan">Zahid H. Chohan</name></noRegion><name sortKey="Shad, Hazoor A" sort="Shad, Hazoor A" uniqKey="Shad H" first="Hazoor A." last="Shad">Hazoor A. Shad</name></country><country name="Maroc"><noRegion><name sortKey="Youssoufi, Moulay H" sort="Youssoufi, Moulay H" uniqKey="Youssoufi M" first="Moulay H." last="Youssoufi">Moulay H. Youssoufi</name></noRegion><name sortKey="Taibi Ben Hadda" sort="Taibi Ben Hadda" uniqKey="Taibi Ben Hadda" last="Taibi Ben Hadda">TAIBI BEN HADDA</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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